Table 2. IFNγR−/− mice are protected from ovx-induced T cell expansion.
T cells in S phase, % | T cells in sub-G0/G1 phase, % | T cells, % of BM white cells | TNF-producing T cells, % of BM white cells | |
---|---|---|---|---|
WT sham | 2.3 ± 0.2 | 2.8 ± 0.4 | 4.51 ± 0.35 | 0.97 ± 0.15 |
WT ovx | 9.9 ± 0.4* | 1.1 ± 0.3* | 8.39 ± 0.59* | 2.35 ± 0.49* |
IFNγR−/− sham | 3.1 ± 0.3 | 2.5 ± 0.3 | 2.79 ± 0.24 | 1.16 ± 0.16 |
IFNγR−/− ovx | 2.2 ± 0.1 | 2.8 ± 0.2 | 2.72 ± 0.43 | 0.94 ± 0.14 |
Ovx fails to increase T cell proliferation (cells in S phase), to decrease T cell apoptosis (cells in sub-G0/G1 phase), and to increase BM T cells in IFNγR−/− mice (mean ± SEM).
P < 0.05 as compared to all other groups.