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. 2003 Aug 15;100(18):10423–10428. doi: 10.1073/pnas.1732494100

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Fig. 3. — Hematoxylin, macrophage, and filipin staining of proximal aortic lesion sections from male Npc1^+/+;Apoe^-/- and Npc1^+/-;Apoe^-/- mice. (A and B) Sections of proximal aortic lesions from 25-week-old cholesterol-fed male Npc1^+/+;Apoe^-/- (A) and Npc1^+/-;Apoe^-/- mice (B). Sections were stained with hematoxylin and eosin (H&E). (×225.) Asterisks indicate acellular areas. The lesion from the Npc1^+/-;Apoe^-/- mouse (B) is markedly more cellular than the lesion from the Npc1^+/+;Apoe^-/- mouse (A). (C) These cells were identified as macrophages (Mϕ) by immunohistochemistry. Inset shows a nonimmune control. (D and E) Lesions from these mice were stained with filipin. Overall lesional accumulation of FC was not markedly different in the two lesions.