Rapid activation of ERK-2 in primary hippocampal neurons treated with
E2, P4, or MPA. Western blots show levels of pERK2 and
total ERK2 in whole-cell lysates from primary hippocampal neurons treated with
E2 (A), P4 (B), MPA (C), or
combined E2 and progestin (D). C, vehicle; E,
E2; P, P4; M, MPA. Bar graphs represent mean ±
SEM; *, P < 0.05 as compared with control; n =
4.