Fig. 4.

AM1241 inhibits tactile hypersensitivity in mice lacking the CB₁ receptor. (A) Sham-operated wild-type mice. (B) Spinal nerve-ligated wild-type mice. (C) Sham-operated CB₁^-/- mice. (D) Spinal nerve-ligated CB₁^-/- mice. BL, presurgical baseline; S, after sham operation; SNL, after spinal nerve ligation. Doses used were as follows: AM1241, 1 mg/kg; AM 630, 1 mg/kg; AM251, 300 μg/kg. Data are expressed as mean ± SEM; n = 6 per group. #, P < 0.05 compared with presurgical baseline; *, P < 0.05 compared with postsurgical values; +, P < 0.05 compared with AM1241 alone.