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. 2003 Aug 19;100(18):10534–10539. doi: 10.1073/pnas.1832721100

Fig. 3.

Fig. 3.

Gating currents of inactivationdeficient S631A HERG channels. Family of gating currents elicited as in Fig. 2 from a HP of -110 mV (a) and 0 mV (b). Test pulses were applied in 20-mV increments. (c) Normalized QOFF-V and G-V relationships. The V1/2 and z were -21 ± 1.4 mV and 1.9 ± 0.1 for the QOFF-V relationship at a HP of -110 mV (n = 9), +9.4 ± 1.4 mV and 2.4 ± 0.1 for the G-V relationship (n = 7), and -82 ± 2.2 mV and 2.1 ± 0.1 for the QOFF-V relationship at a HP of 0 mV (n = 7). (d)Q2ms/Q300ms as a function of test potential (n = 4). (e) Voltage dependence of QFAST was determined as in Fig. 2e. The V1/2 and z were +32 ± 1.5 mV and 0.7 ± 0.01 (n = 5). (f and g) IgOFF for WT (f) and S631A (g) HERG elicited by pulses to -110 mV after a 300-ms test pulse to +30 mV (trace 1), 0 mV (trace 2), -30 mV (trace 3), and -60 mV (trace 4).