Table 1.
COPP-ABVD, standard-dose BEACOPP, and increased-dose BEACOPP dosage regimens (Diehl et al 2003)
COPP-ABVDa | Standard-dose | BEACOPPb | Increased-dose | |||
---|---|---|---|---|---|---|
BEACOPPb | ||||||
Single dose (mg/m2) | Days given | Single dose (mg/m2) | Days given | Single dose (mg/m2) | Days given | |
Bleomycin | 10 iv | 29 and 43 | 10 iv | 8 | 10 iv | 8 |
Etoposide | − | − | 100 iv | 1–3 | 200 iv | 1–3 |
Doxorubicin | 25 iv | 29 and 43 | 25 iv | 1 | 35 iv | 1 |
Cyclophosphamide | 650 iv | 1 and 8 | 650 iv | 1 | 1200 iv | 1 |
Vincristine | 1.4 iv | 1 and 8 | 1.4 iv | 8 | 1.4 iv | 8 |
Procarbazine | 100 po | 1–14 | 100 po | 1–7 | 100 po | 1–7 |
Prednisone | 40 po | 1–14 | 40 po | 1–14 | 40 po | 1–14 |
Vinblastine | 6 iv | 29 and 43 | - | - | - | - |
Dacarbazine | 375 iv | 29 and 43 | - | - | - | - |
Note: aregimen repeated on day 57;
regimen repeated on day 22.
Abbreviations: BEACOPP, bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone; COPP-ABVD, alternating cyclophosphamide, vincristine, procarbazine, and prednisone with doxorubicin, bleomycin, vinblastine, and dacarbazine; iv, intravenous; po, oral.