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Pharmacokinetic characteristics of dapoxetine compared with paroxetine and sertraline
| Dapoxetine | Paroxetine | Sertraline | |
|---|---|---|---|
| Dose (mg) | 60 | 40 | 100 |
| Cmax(ng/mL) | 386.0 | 19.0 | 22.7 |
| Tmax(h) | 1.5 | 6.83 | 6.4 |
| T1/2a(h) | 1.03 | 3.93 | 3.57 |
| T1/2b(h) | 21.9 | 46.7 | 39.5 |
| C24 (% of peak) | 3.67 | 45.1 | 47.8 |
| Accumulation | 1.3 | 2.45 | 2.68 |
Derived from Gengo et al (2005), Hellstrom (2004), Hellstrom et al (2005), Andersson et al (2006).
