. 2007 Jun;3(2):333–339. doi: 10.2147/tcrm.2007.3.2.333

Table 3.

Guidelines for prophylactic therapy for children at risk for nausea and vomiting

Risk category	PONV^a	CINV^b, ^c	RINV^c
High	5-HT3 rcpt Antagonists plus corticosteroids plus drug of another class^d	5-HT3 rcpt Antagonists plus corticosteroids plus drug of another class^d	Corticosteroids plus 5-HT3 rcpt antagonists
Moderate	5-HT3 rcpt Antagonists plus corticosteroids or drug of another class^d	5-HT3 rcpt Antagonists plus corticosteroids or drug of another class^d	Corticosteroids or 5-HT3 rcpt antagonists
Low	No prophylaxis	Corticosteroids or 5-HT3 rcpt antagonists	No prophylaxis

Gan et al (2003);

Dupuis and Nathan (2003);

Aapro (2005).

Notes:Dopamine antagonists (metoclopramide, droperidol, and prochlorpromazine) or substance P/neurokinin 1 (NK1) receptor antagonist (aprepitant) pending pediatric studies.

Abbreviations:CINV, chemotherapy-induced nausea and vomiting; PONV, postoperative nausea and vomiting; rcpt, receptor; RINV, radiation-induced nausea and vomiting.