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CALGB Azacytidine trials
| Trial 8421 Phase I | Trial 8921 Phase II | Trial 9221 RCT | ||
|---|---|---|---|---|
| Intravenous | Subcutaneous | Supportive care | Azacytidine | |
| Patient evaluated | 43 | 68 | 92 | 99 |
| CR | 5 (12%) | 8 (12%) | 0 (0%) | 7(7%)* |
| PR | 11 (25%) | 10 (15%) | 0 (0%) | 16 (16%)+ |
| Improved | 5 (12%) | 18 (27%) | 5 (5%) | 37 (37%)+ |
| Total response | 21 (49%) | 36 (53%) | 5 (5%) | 60 (60%)+ |
Note: p=0.01,
p<0.0001
Abbreviations: CALGB, Cancer And Leukemia Group B; CR, complete response; PR, partial response, RCT, randomized controlled trial.
