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Concentration of meropenem in tissues involved in complicated skin and soft tissue infections
| Dose | Sample | Mean drug concentration (mg/L) | Tissue/fluid:serum | |||
|---|---|---|---|---|---|---|
| Body tissue or fluid | N | (g) | time (hrs) | Tissue/fluid | Serum | Ratio |
| Skeletal muscle | 14 | 1 | 0.5–4.5 | 0.93–6.10 | – | – |
| Fascia | 18 | 1 | 0.5–5.5 | 0.99–8.76 | – | – |
| Skin | 3 | 0.5 | 0 | 3.97 | 42.6 | 9.6% |
| 0.5 | 1 | 3.4 | 11.9 | 33.5% | ||
| Burned skin | 2 | 1 | 0 | 5.5 | 64.3 | 8.8% |
| 1 | 1 | 9.2 | 14.8 | 61.6% | ||
| Blister fluid | 8 | 10 mg/kg | 3.5–4.5 | 1.36 | 1.44 | 85% |
| Blister fluid | 6 | 1 | 3.5–4.5 | 4.94 | 2.07 | >38% |
