Table 2.
In vitro activity of moxifloxacin against potential bite wound pathogens and Gram-positive and Gram-negative anaerobic pathogens in SSSIs
| Organism | Isolates (n) | Range of MIC90s (mg/L) | References |
|---|---|---|---|
| Pasturella canis | 53 | 0.015–0.063 | (1, 12, 25) |
| P. multocidasubsp. multocida | 217 | 0.015–0.06 | (1, 2, 12, 25) |
| P. multocidasubsp. septicum | 104 | 0.016–0.03 | (1, 2, 12, 25) |
| P. stomatis | 48 | ≤0.015–0.125 | (1, 12, 25) |
| Ef-4b | 38 | 0.06–0.25 | (1, 2) |
| Eikenella corrodens | 40 | 0.06–0.125 | (1, 2) |
| Peptostreptococci | 376 | 0.25–2 | (1, 6, 7, 9, 13–18) |
| Clostridium perfringens | 312 | 0.25–4 | (5–9, 13–18, 26, 27) |
| C. difficile | 344 | 1–4 | (4, 6, 7, 9, 11, 13–17) |
| Bacteroides fragilis | 2132 | 0.25–8 | (3–6, 8–10, 13–24, 26, 27) |
| B. vulgatus | 357 | 1–≥32 | (5, 14–16, 18–22, 24, 26, 27) |
| B. ovatus | 407 | 2–32 | (5, 15, 16, 18–22, 24, 26, 27) |
| B. thetaiotaomicron | 735 | 1–32 | (5, 6, 8, 14–16, 18–24, 26, 27) |
| B. distasonis | 199 | 0.5–8 | (5, 14–16, 18, 24, 26, 27) |
| Fusobacterium sp. | 307 | 0.12–>8 | (1, 5, 6, 8, 14–19, 22, 26, 27) |
| F. nucleatum | 129 | 0.125–>8 | (1, 2, 5, 13–16, 26, 27) |
| Prevotellasp. | 130 | 0.5–4 | (1, 5, 7, 19, 22, 26, 27) |
Abbreviations: MIC90= minimum inhibitory concentration for 90% of isolates.
Notes: For entries with multiple studies, data are the range.To be included, studies had to have a minimum of 10 isolates of the microorganism-of-interest, use a National Committee for Clinical Laboratory Standards – approved methodology, and an inoculum of 104–106organisms.
References: 1, Goldstein et al 2000; 2, Goldstein et al 1997; 3, Speciale et al 2002; 4, Bauernfeind 1997; 5, Edmiston et al 2004; 6, Fung-Tomc et al 2000; 7, Milatovic et al 2000; 8, Fass 1997; 9,Woodcock et al 1997; 10, Dalhoff et al 1996; 11, Hoogkamp-Korstanje et al 2000; 12, Goldstein et al 2002; 13, Sillerstrom et al 2004; 14, Peric et al 2004; 15, Ednie et al 2003; 16, Hoellman et al 2001; 17, Edlund et al 1998; 18, Aldridge and Ashcraft 1997; 19, Schaumann et al 2000; 20, MacGowan et al 1997; 21, Snydman et al 2002; 22, Ackermann et al 2000; 23, Betriu et al 1999, 24, Hedberg et al 2003; 25, Lion et al 2006; 26, Goldstein et al 2005; 27, Edmiston et al 2005.