Table 1.
Agent | Characteristics |
---|---|
Cetuximab | Chimeric human-mouse IgG1 Mab |
Matuzumab (EMD 72000) | Humanised IgG1 Mab |
Panitumumab (ABX-EGF) | Fully human IgG2 Mab |
h-R3 | Humanised IgG1 Mab |
OSI-774 (Erlotinib) | Reversible TKI |
ZD-1839 (Gefitinib) | Reversible TKI |
EKB-569 | Irreversible TKI |
GW-016(Lapatinib) | EGFR/HER2, reversibleTKI |
CI-1033 | Pan-erB TKI |
Abbreviations: EGFR, epithelial growth factor receptor; IgG, immunogloblin; Mab, monoclonal antibody;TKI, tyrosine kinase inhibitor.