Table 1.

Therapeutic approaches to targeting the epidermal growth factor receptor

Agent	Characteristics
Cetuximab	Chimeric human-mouse IgG1 Mab
Matuzumab (EMD 72000)	Humanised IgG1 Mab
Panitumumab (ABX-EGF)	Fully human IgG2 Mab
h-R3	Humanised IgG1 Mab
OSI-774 (Erlotinib)	Reversible TKI
ZD-1839 (Gefitinib)	Reversible TKI
EKB-569	Irreversible TKI
GW-016(Lapatinib)	EGFR/HER2, reversibleTKI
CI-1033	Pan-erB TKI

Abbreviations: EGFR, epithelial growth factor receptor; IgG, immunogloblin; Mab, monoclonal antibody;TKI, tyrosine kinase inhibitor.