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Toxicities associated with the combination of erlotinib and gemcitabine in the NCIC Phase III study
| Toxicity | Gemcitabine plus erlotinib (%) n=282 | Gemcitabine plus placebo (%) n=280 | ||
|---|---|---|---|---|
| Any | Grade 3/4 | Any | Grade 3/4 | |
| Rash | 72 | 6 | 29 | 1 |
| Diarrhea | 56 | 6 | 41 | 2 |
| Neutropaenia | 31 | 25 | 28 | 26 |
| Thrombocytopaenia | 64 | 10 | 66 | 12 |
| Infection | 43 | 17 | 34 | 16 |
| Stomatitis | 23 | <1 | 14 | 0 |
| Pneumonitis | 2 | 2 | 1 | <1 |
| Fatigue | 89 | 15 | 86 | 15 |
| Dehydration | 8 | 3 | 10 | 5 |
Abbreviations: NCIC, National Cancer Institute of Canada.
