Table 4.

Some key mode and resource use with antimicrobials specific for resistant Gram-positive infections. Linezolid compared with standard of care antimicrobials for methicillin-resistant Gram-positive cocci infections (vancomycin and teicoplanin), and with the currently available alternatives recently introduced into the market (quinupristin/dalfopristin, and daptomycin)

	Linezolid	Vancomycin	Teicoplanin	Quinupristin/dalfopristin	Daptomycin	Tigecycline	Dalbavancin
IV and oral route, both available	Yes	No*	No*	No	No	No	No
Ambulatory (outpatient)	Yes	No	Yes	Yes?	?	?	Yes
administration feasible
Need of serum drug level monitoring	No	Yes	No	Yes	Yes?	No	No
Frequency of drug administration	Twice daily	At least twice daily, to 24 h continue infusion	Once daily	Once daily	Once daily	Twice daily	Once weekly

Abbreviations: IV, intravenous.

^*Note: indication restricted to the management of Clostridium difficile-associated diarrhea.