Table 3.
Examples of recent mouse gene duplications
| Locus1* | Gene | Percent identity† | Annotation | Locus2* | Gene | Percent identity† | Annotation | Duplication % identity‡ |
| 1 F | NM_009888 | 99.6 | Cfh (Complement component factor h) | 1 F | M29010 | 99.0 | Complement factor H-related protein mRNA | 97.1 |
| 3 G1 | NM_009669 | 100 | Amy2 (Amylase 2, pancreatic) | 3 G1 | M11896 | 99.6 | Pancreatic amylase B-1 | 97.6 |
| 5 E2 | NM_053184 | 99.9 | Ugt2a1 (UDP glycosyltransferase 2 A1) | 5 E2 | BF144793 | 99.6 | cDNA clone IMAGE:4021939 | 95.7 |
| 5 E2 | NM_009467 | 100 | Ugt2b5(UDP-glucuronosyl-transferase 2b5) | 5 E2 | NM_053215 | 100 | RIKEN cDNA 0610033E06 gene | 93.3 |
| 5 E4 | NM_008620 | 99.9 | Mpa2 (macrophage activation 2) | 5 E4 | BC007143 | 99.5 | Similar to macrophage activation 2 | 90.6 |
| 5 G1 | NM_029693 | 100 | RIKEN cDNA 1700123K08 | 7 B2 | NM_027702 | 100 | RIKEN cDNA 4933421I07 gene | 91.1 |
| 6 C1 | NM_053238 | 100 | V1rc8 (Vomeronasal 1 receptor, C8) | 6 C1 | NM_053239 | 99.7 | V1rc9 (Vomeronasal 1 receptor, C9) | 95.1 |
| 6 D1 | NM_011467 | 99.9 | Spr (sepiapterin reductase) | 6 D1 | BE862957 | 99.5 | EST sequence | 95.8 |
| 6 F1 | AI505330 | 100 | Similar to initiation factor eIF-4AI | 6 F1 | AI503670 | 99.8 | Similar to initiation factor eIF-4AI | 98.9 |
| 6 F2 | NM_008646 | 99.9 | Mug2 (Murinoglobulin 2) | 6 F2 | NM_008645 | 99.9 | Mug1 (Murinoglobulin 1) | 94.6 |
| 6 F3 | NM_020257 | 99.8 | Dcl1 (c-type lectin 1) | 6 F3 | NM_027562 | 99.9 | 4632413B12Rik (C-lectin related protein) | 90.8 |
| 6 F3 | NM_008463 | 99.7 | Klra5 (Killer cell lectin-like receptor, A5) | 6 F3 | NM_008464 | 99.5 | Klra6 (Killer cell lectin-like receptor, A6) | 90.0 |
| 6 F3 | NM_010649 | 99.8 | Klra4 (Killer cell lectin-like receptor A4) | 6 F3 | NM_016659 | 99.8 | Klra1 (Killer cell lectin-like receptor A1) | 91.4 |
| 6 F3 | NM_010737 | 99.8 | Klrb1b (Killer cell lectin-like receptor 1b) | 6 F3 | NM_008527 | 99.9 | Klrb1c (Killer cell lectin-like receptor 1c) | 90.8 |
| 7 A2 | NM_011860 | 100 | Mater (Maternal effect gene) | 7 A1 | AK016782 | 100 | Similar to Mater protein | 96.6 |
| 7 B1 | NM_032541 | 100 | Hamp hepcidin antimicrobial peptide | 7 B1 | AK007975 | 99.8 | Prohepcidin homolog | 92.8 |
| 7 B2 | NM_010115 | 99 | Klk13 (Kallikrein 13) | 7 B2 | NM_008454 | 99.9 | Klk16 (Kallikrein 16) | 92.2 |
| 8 D1 | L11333 | 99.9 | Carboxylesterase | 8 D1 | NM_144511 | 100 | Es31 | 95.2 |
| 9 F4 | NM_130864 | 99.6 | Acaa acetyl-Coenzyme A acyltransferase | 9 F4 | BC019882 | 100 | Similar to acetyl-CoA acyltransferase | 96.6 |
| 10 B3 | NM_013532 | 99.9 | Gp49a (Glycoprotein 49A) | 10 B3 | NM_008147 | 100 | Gp49b (glycoprotein 49B) | 96.7 |
| 10 D2 | NM_017372 | 100 | Lyzs (Lysozyme) | 10 D2 | NM_013590 | 99.8 | Lzp-s (P lysozyme structural) | 95.3 |
| 11 A3.2 | NM_172792 | 100 | hypothetical protein 4932414J04 | 17 D | AK03001 | 100 | Tyrosine protein kinase/cysteine-rich region | 94.0 |
| 11 B1.3 | NM_011396 | 99.9 | Slc22a5 (Solute carrier family 22) | 11 B1.3 | NM_019723 | 100 | Slc22a9 (solute carrier family 22) | 91.2 |
| 11 D | NM_021347 | 100 | Gsdm (Gasdermin) | 11 D | NM_029727 | 99.9 | 2200001G21Rik | 94.2 |
| 12 F1 | BC002065 | 99.6 | Serine protease inhibitor 2-1 | 12 F1 | BY761363 | 99.9 | EST sequence | 92.2 |
| 12 F1 | NM_013772 | 100 | Tcl1b3 (T-cell leukemia/lymphoma 1B, 3) | 12 F1 | NM_013776 | 100 | Tcl1b5 (T-cell leukemia/lymphoma 1B, 5) | 95.3 |
| 13 A1 | NM_013778 | 99.5 | Akr1c13 (Aldo-keto reductase 1, C13) | 13 A1 | NM_013777 | 99.5 | Akrc12 (Aldo-keto reductase 1, C12) | 96.1 |
| 13 A3 | NM_008864 | 99.2 | Csh1 (chorionic somatomammotrophin 1) | 13 A3.3 | AK082929 | 100 | Similar to placental lactogen 1 | 98.8 |
| 13 A4 | NM_011456 | 100 | Spi14 (Serine Protease Inhibitor 14) | 13 A4 | NM_011455 | 100 | Spi13 (serine protease inhibitor 13) | 95.2 |
| 13 D1 | NM_010872 | 100 | Birc1b (Neuronal apoptosis inhibitory 2) | 13 D1 | NM_008670 | 99.9 | Birc1a (Neuronal apoptosis inhibitory 1) | 90.0 |
| 14 C1 | NM_010373 | 99.7 | Gzme (Granzyme E) | 14 C1 | NM_010372 | 99.9 | Gzmd (Granzyme D) | 94.7 |
| 14 C2 | NM_172603 | 100 | 4933417L10Rik | 14 C3 | BE381578 | 100 | EST sequence | 94.0 |
| 15 E2 | NM_007781 | 100 | Csf2rb2 (Colony stimulating factor 2, β-2) | 15 E2 | NM_007780 | 99.8 | Csf2rb1 (Colony stimulating factor 2, β-1) | 95.0 |
| 15 E2 | NM_010005 | 100 | Cyp2d10 (Cytochrome P450, 2d10) | 15 E2 | NM_010006 | 100 | Cyp2d9 (cytochrome P450, 2d9) | 92.1 |
| 16 B1 | NM_023125 | 100 | Kng (Kininogen) | 16 B1 | BI330914 | 99.1 | EST sequence | 90.0 |
| 16 B3 | M92418 | 99.8 | MS2 (Cysteine proteinase inhibitor) | 16 B3 | BB654253 | 100 | EST sequence | 95.2 |
| 17 B2 | NM_009780 | 99.9 | C4 (Complement component 4) | 17 B2 | M21576 | 99.5 | Slp (MHC sex-limited protein) | 96.3 |
| X A2 | NM_008955 | 100 | Psx1 (Placenta specific homeobox 1) | X A2 | NM_023894 | 100 | Homeobox protein GPBOX | 91.6 |
*Locations of duplicons by mouse chromosome banding; locus 1 and 2 represent a duplication pair. †Alignment percent identity between gene and genomic sequences showing correct matches. ‡ % similarity: average DNA percent identity between paralogous gene/transcript sequences in locus 1 and 2 (duplicated pair)