Table 2.
No strain differences in affinity (Ki) or number (Bmax) of DAT binding sites measured with [3H]WIN 35,428 binding to membranes of dSTR and NAc from LEW and F344 rats.
| Ki(nM) | Bmax (pmol/mg protein) |
|
|---|---|---|
| dSTR (n = 6/strain) | ||
| LEW | 14.5 ± 1.09 | 2.21 ± 0.13 |
| F344 | 13.9 ± 1.69 | 2.61 ± 0.25 |
| NAc (n = 5/strain) | ||
| LEW | 7.26 ± 1.84* | 0.76 ± 0.14* |
| F344 | 7.83 ± 1.04* | 0.93 ± 0.15* |
Data from the NAc of one LEW and one F344 rat were excluded from the analysis due to technical problems with the assay.
*
p < 0.01, within-strain comparisons between dSTR and NAc for Ki and p < 0.001 for Bmax.