Skip to main content
. 2007 Aug 15;2(8):e735. doi: 10.1371/journal.pone.0000735

Figure 4. Loss of CD27 on tuberculin-reactive CD4 T-cells identifies smear and/or culture positive TB.

Figure 4

A: Patients with smear and/or culture positive pulmonary TB were distinguishable from those with smear and culture negative pulmonary TB using a threshold of 48% (dotted line). Patients more than 1 year after beginning of treatment mostly had values >48% if TB was initially smear positive (empty squares), and <48%, if TB was smear negative (filled squares). Statistically significant differences are indicated (Chi-square test). Primary end-point was the percentage of CD27-negative cells among reactive cells. Vertical numbers indicate the number of evaluated events (median and range). B: Loss of CD27 expression on tuberculin and ESAT-6 specific CD4 T-cells is closely correlated.