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. 2003 Sep 15;112(6):924–934. doi: 10.1172/JCI15543

Figure 7.

Figure 7

Phenotype of a 4-month-old noggin-overexpressing mouse. Expression of noggin mRNA detected by RT-PCR in liver (L), kidney (K), and bone (B), and by Western blotting in bone (a) in WT and noggin transgenic (TG) littermates; GAPDH was used as a control. (b) Radiology of the femur; (c) bone mineral density of the femur, tibia, spine (L4–L6), and total body; and (d) H&E staining of femur were performed to show differences between WT and noggin transgenic mice. Comparison of bone marrow cell cultures isolated from WT and noggin transgenic mice to evaluate ALP-positive CFU-F, CFU-OB (e), and TRAP-positive osteoclast formation (f). Results are expressed as mean ± SEM. *P < 0.05, significantly different from WT mice by ANOVA.