Figure 2.

Time course of long-term oral ²H₂O label incorporation into CD4⁺ and CD8⁺ T cell DNA in different groups. (a) Time course of fractional synthesis of T cell DNA in different clinical groups. f, fractional synthesis or percent newly divided cells present, as described in Results. (b) ²H₂O enrichment in body water. ²H₂O was given as an initial loading dose on day 0 then given daily for 9 weeks by mouth. Urine and saliva were collected weekly and ²H₂O enrichment was measured by GC/MS (10, 22). (c) ²H-enrichment in blood monocytes/granulocytes (average for group as a whole). (d) Summary of phase I and phase II T cell proliferation during long-term ²H₂O incorporation in the three groups: healthy controls, untreated HIV-1/AIDS, and LT ARV therapy. *P < 0.05 vs. normal controls; **P < 0.05 vs. HIV-1/AIDS. Number of subjects shown above bars. Data shown are mean ± SD.