Accelerated renal lesion development in the absence of JunD. Morphology and lesion scores of remnant kidneys from JunD+/+ (white bars) and JunD–/– (black bars) mice 60 days after nephron reduction (Nx). Renal lesions were graded according to established methodology in randomly selected microscopic fields of the cortex. (a) Glomerular lesions, ×400. (b) Tubular lesions, ×200. (c) Interstitial fibrosis, ×200. (d) Interstitial mononuclear cell infiltration, ×200. Results represent mean ± SEM; n = 6. #P < 0.05, ##P < 0.01, JunD–/– versus JunD+/+ by Mann-Whitney test.