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. 2003 Sep 15;112(6):843–852. doi: 10.1172/JCI17647

Figure 4.

Figure 4

Elevated TGF-α expression in the absence of JunD. (a) EGF and TGF-α mRNA expression in control nonoperated (C) and remnant (Nx) kidneys of JunD+/+ (white bars) and JunD–/– (black bars) mice at day 60. Data are mean ± SEM; n = 6 for each point. *P < 0.05, **P < 0.01, remnant versus control kidneys; ###P < 0.001, JunD–/– versus JunD+/+ kidneys by ANOVA, followed by Tukey-Kramer test. (b) Immunohistochemistry of EGF (upper) and TGF-α (lower) expression in control nonoperated and remnant (Nx) kidneys of JunD+/+ and JunD–/– mice at day 60 (×200). (c) Immunoblot analysis of TGF-α expression in control nonoperated (C) and remnant (Nx) kidneys of JunD+/+ and JunD–/– mice at day 60. Extracts of TGF-α–/– kidneys served as negative controls.