Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Complementary functions of class I and class II HDACs in cardiac hypertrophy. (a) The myocyte enhancer factor-2–based transcriptional program that triggers cardiac hypertrophy is repressed by signal-responsive class II HDACs, which are exported from the nucleus as the result of hypertrophic cues (1, 2). (b) A class I HDAC (HDAC2) is recruited to SRF — via Hop as an intermediary — thereby blocking a transcriptional program that opposes hypertrophy (14). MEF2, myocyte enhancer factor-2.
