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. 2003 Sep;23(18):6542–6552. doi: 10.1128/MCB.23.18.6542-6552.2003

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FIG. 4. — Additional, novel tumor types arise in Rb^+/−; E2f3^−/− mice. (A) Comparison of normal islets (N) in a wild-type mouse with islet-cell tumors (T) from two Rb^+/−; E2f3^−/− mice. Magnification, ×20. (B) Histological appearance of a typical Rb mutant intermediate-lobe (IL) pituitary tumor versus that of pituitary tumors from two different Rb^+/−; E2f3^−/− mice who had tumors initiating in both the intermediate lobe and the anterior lobe (AL) or solely in the anterior lobe of the pituitary gland. Magnification, ×40. (C) A pheocytochroma, a parathyroid tumor, and a uterine endometrial adenoma detected in different Rb^+/−; E2f3^−/− mice. (D) Incidences of various lesions in Rb^+/−, Rb^+/−; E2f3^+/−, Rb^+/−; E2f3^−/−, and E2f3^+/− mice. Magnification, ×40.