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Targeted disruption of the IMPDH type I gene. Shown are a schematic diagram of the IMPDH type I gene with exons 2 to 14 (open boxes), the targeting construct with exons 3 to 9 and exons 9 to 13 cloned adjacent to the neo gene, and the expected result of homologous recombination. The 2.3-kb XbaI fragment used as a probe for Southern analysis and oligonucleotides (E8F, NeoR, and E10R) used for PCR are indicated.
