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Effects of loss of IMPDH and HPRT activities on the cytolytic activities of cytotoxic T lymphocytes. The functions of cytotoxic T lymphocytes from wild-type (100%), IMPDH type I−/− (n = 3) (A), type I−/− HPRT−/0 (n = 5) (B), or type I−/− type II+/− (n = 6) (C) mice were analyzed in 51Cr release assays. Data are means ± standard deviations. Assays were performed in triplicate.
