Table 4.
Incidences of nonneoplastic and neoplastic lesions of the liver in B6C3F1 mice exposed to benzophenone in feed for 2 years
| 0 ppm | 312 ppm | 625 ppm | 1,250 ppm | |
|---|---|---|---|---|
| Males | ||||
|
| ||||
| Number Examined | 50 | 50 | 50 | 50 |
| Hepatocellular Adenoma, Multiple a | 2 | 8* | 8* | 12** |
| Hepatocellular Adenoma (includes multiple) | 11 | 15 | 23* | 23* |
| Hepatocellular Carcinoma | 8 | 5 | 6 | 6 |
| Hepatoblastoma | 0 | 1 | 1 | 3 |
| Clear Cell Focus | 2 | 7 | 7 | 12** |
| Eosinophilic Focus | 5 | 8 | 11 | 10 |
| Mixed Cell Focus | 8 | 9 | 15 | 13 |
| Hepatocyte, Centrilobular, Hypertrophy | 0 | 44** (2.0) b | 50** (2.0) | 48** (3.0) |
| Hepatocyte, Multinucleated | 0 | 41** (1.4) | 47** (1.5) | 48** (1.8) |
| Hepatocyte, Necrosis | 1 (1.0) | 6 (1.7) | 8* (1.8) | 8* (1.3) |
| Inflammation, Chronic Active | 33 (1.0) | 47** (1.1) | 44** (1.2) | 42* (1.1) |
| Hepatocyte, Degeneration, Cystic | 0 | 0 | 5* (1.2) | 30** (1.9) |
|
| ||||
| Females | ||||
|
| ||||
| Number Examined | 50 | 50 | 50 | 50 |
| Hepatocellular Adenoma, Multiple | 1 | 1 | 3 | 3 |
| Hepatocellular Adenoma (includes multiple) | 5 | 4 | 10 | 8 |
| Hepatocellular Carcinoma | 0 | 1 | 0 | 1 |
| Eosinophilic Focus | 2 | 2 | 7 | 7 |
| Hepatocyte, Centrilobular, Hypertrophy | 0 | 29** (2.0) | 44** (2.0) | 37** (2.9) |
*
Significantly different (p ≤ 0.05) from the control group by the Poly-3 test
**
p ≤ 0.01
a
Number of animals with lesions
b
Average severity grade of lesions in affected animals: 1=minimal, 2=mild, 3=moderate, 4=marked