Table 4.

Characteristic motifs in UDGs (Example: E. coli UDG [2EUG] and human UDG [1AKZ]) and variations as seen in vvUDG (2OWQ, 2OWR).

	2EUG	1AKZ	2OWQ, 2OWR
Catalytic water-	62-GQDPYH-67	143-GQDPYH-148	66-GIDPYP-71
activating-loop
Pro-rich loop	84-AIPPS-88	165-PPPPS-169	-
Uracil specificity	120-LLLN-123	201-LLLN-204	117-IPWN-120
Gly-Ser loop	165-GS-166	246-GS-247	-
Leu intercalation loop	187-HPSPLSAHR-195	268-HPSPLSVYR-276	179-GYHPAARDR-187
Active site residues	D64, Y66, F77, N123, H187, L191	D145, Y147, F158, N204, H268, L272	D68, Y70, F79, N120, H181