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. 2007 Aug 3;3(8):e128. doi: 10.1371/journal.pgen.0030128

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© 2007 O'Rourke et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Effect of reducing the function of 49 genes on embryonic viability in the dhc-1(or195) mutant. E. coli containing the L4440 control vector produced 1.6% viable progeny at 23 °C, while the suppressor genes produced the indicated percent viable progeny when reduced in function with RNAi.

(B) Deletion and point mutation double mutants recapitulate the suppression of conditional dhc-1 alleles observed using RNA interference. Embryonic viability of wild type, dhc-1, and dhc-1 suppressor gene double mutants is displayed. The dhc-1 unc-29 strain serves as the negative control for the dhc-1 unc-29 dylt-1 strain.