Figure 4.
Cellular distribution of Cys–X–Cys receptor (CXCR)3 protein in synovial tissue from rheumatoid arthritis (RA) patients. Localization of strong CXCR3 protein signals in mast cells within the sublining areas of rheumatoid synovial tissues was found. Sequential sections of paraffin-embedded tissue were stained for CXCR3 and mast cell tryptase proteins or using an IgG1 isotype-matched control. Each arrow refers the same cell that was positively stained for CXCR3 and mast cell tryptase (original magnification: upper panel × 200; lower panel × 400).