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Differentiation of naive CD4+ T cells (CD45RA+) towards memory CD4+ T cells (CD45RO+) in rheumatoid arthritis (RA) patients and in healthy controls after CD3/CD28 costimulation for 5 and 10 days. The numbers in each quadrant indicate the percentage of CD45RA+ (upper left), CD45RO+ (lower right) and CD45RA+ CD45RO+ double positive cells (upper right). PE, phycoerythrin; FITC, fluorescein isothiocyanate.
