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. Author manuscript; available in PMC: 2008 Jun 28.
Published in final edited form as: Vaccine. 2007 May 15;25(27):5034–5040. doi: 10.1016/j.vaccine.2007.04.075

Fig. 4.

Fig. 4

Exacerbation of pulmonary pathology in hMPV challenged cotton rats vaccinated with FI-hMPV. Medium power photomicrographs of cotton rat lungs at various days after challenge with human metapneumovirus. Each frame is centered on a bronchiole that is accompanied by a blood vessel. Pulmonary histopathology by days post-challenge (4, 7, and 10) with human metapneumovirus in cotton rats with a primary infection, reinfection, or that received mock or formalin-inactivated metapneumovirus vaccine before challenge. Pathology score from 0 to 4 scale in severity of infiltration of inflammatory cells using four parameters (Peribronchiolitis, Perivasculitis, Interstitial Pneumonitis, and Alveolitis).