Figure 1.

Organization of hMSH6 genomic locus and sequence of the intron region flanking each MSH6 exon. Boxes containing numbers 1 through 10 indicate the individual MSH6 exons and their relative sizes. The size of each exon is given below each exon and the size of each intron is given above the region between each pair of exons. The sizes of exons 1 and 10 are the sizes of the mRNA sequence upstream and downstream of the first and last introns, respectively; these sizes were calculated from the longest MSH6 cDNA sequence available. The first 20 nucleotides of each intron sequence up to the intron-exon junction is given in uppercase letters except for the 3′ side of the last intron, where additional sequence is given. The first 10 nucleotides of each exon sequence up to the intron-exon junction is given in lowercase letters. In addition, the sequence of the 5′ and 3′ ends of the cDNA, minus the poly(A) sequence, is also given in lowercase letters. The numbers in parentheses between intron sequences are the nucleotide coordinates of the exon sequences or cDNA sequences, assuming the A of the ATG is nucleotide 1. (Additional intron sequence including the complete sequence of some introns has been determined in all cases and is available on request from M.F.K. and R.K.)