FIG. 1.

(a) Structure of the HPI core in Y. enterocolitica. Bars indicate genes, and arrows indicate gene clusters and the direction of transcription (20). intB, gene for P4-like integrase (see also text); H, HincII; P, PstI; Sp, SphI; S, SalI. (b) Alignment of chorismate binding proteins PmsC (ICS of P. fluorescens), Irp9 (Y. enterocolitica), and TrpE2/MtbI (putative anthranilate synthase of M. tuberculosis). Black bars indicate the regions of high homology comprising the predicted chorismate binding sites. Similarities for Irp9/PmsC and Irp9/TrpE₂ are indicated.