Figure 9. Pro- and anti-apoptotic proteins that govern the extrinsic and intrinsic cell death pathways.

Proapoptotic proteins are shown in italic, antiapoptotic proteins in bold. TNF-induced signaling involves the formation of 2 sequential signaling complexes, complex I and complex II. Complex I is bound to TNF receptor superfamily, member 1 (TNFR1) and contains TNFR1-associated death domain (TRADD), TNFR-interacting serine-threonine kinase (RIP), and TNFR-associated factor 2 (TRAF2). Complex II is located in the cytosol and contains TRADD, RIP1, Fas-associated death domain (FADD), and caspase-8. See Discussion for further details.