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. 2007 Aug 9;117(9):2539–2552. doi: 10.1172/JCI31183

Figure 10. Administration of Wy14,643 i.

Figure 10

. in WT and FASKO mice. (A and B) Effect of a single i.p. injection of vehicle (20% dimethyl sulfoxide in saline) and Wy14,643 (15 μg) on food intake (left panels) and body weight change (right panels) in WT and FASKO mice following a 23.5-hour fast. (C and D) Effect of i.p. injection of vehicle and Wy14,643 on mRNA levels by quantitative RT-PCR of PPARα and its target genes (ACO and CPT-1) in the liver (C) and hypothalamus (D) after 24 hours of refeeding in WT and FASKO mice. Data represent mean ± SEM for 5–6 animals per genotype per group. *P < 0.05 compared with corresponding WT; #P < 0.05 compared with corresponding vehicle-treated animals.