Figure 12. A proposed model for the role of hypothalamic FAS and PPARα in the regulation of feeding behavior.

FASKO mice exhibit a lean hypophagic phenotype with impaired hypothalamic PPARα signaling. FAS is regulated by many factors associated with the fed state whereas PPARα is induced in the fasted state. Activation of PPARα in the CNS induces CPT-1 and MCD expression and decreases malonyl-CoA content, thereby forming an integrative sensory module to affect feeding homeostasis.