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. 2007 Aug 9;117(9):2539–2552. doi: 10.1172/JCI31183

Figure 8. Administration of PPARα agonist i.

Figure 8

.v. restores PPARα signaling and normalizes food intake in FASKO mice. (A and B) Effect of a single i.c.v. injection (2 μl) of vehicle (20% dimethyl sulfoxide in artificial cerebrospinal fluid) and Wy14,643 (Wy; 15 μg) on food intake (left panel) and body weight change (right panel) in WT and FASKO mice following a 23.5-hour fast. (C) Effects of i.c.v. injection of vehicle (Veh) and Wy14,643 (Wy) on mRNA levels of PPARα and its target genes (ACO, CPT-1 and MCD) in the hypothalamus by quantitative RT-PCR after 24 hours of refeeding. (D) Effects of i.c.v. injection of vehicle and Wy14,643 on hypothalamic malonyl-CoA content after 24 hours of refeeding. (E and F) Effect on food intake and body weight change in WT and FASKO mice initially treated with Wy14,643 and then treated with vehicle 7 days later. All results represent mean ± SEM for n = 7 per genotype for vehicle and n = 10 per genotype for Wy groups. *P < 0.05 compared with corresponding WT; #P < 0.05 compared with corresponding vehicle-treated animals; **P < 0.05 compared with vehicle-treated FASKO mice.