Fig. 3.
The effect of FXI antibody 5061 on the activation of the coagulation cascade in a plasma environment. (A) FXI antibody concentration response. Normal plasma was stimulated by recalcification (open symbols) or by recalcification and TF (1/106, filled circles) in the presence of the indicated concentration of FXI antibody 5061. Total IgG concentration (specific and nonspecific) was adjusted to 50 μg/ml. Each concentration was tested in triplicates. (B) The specificity of antibody 5061. Normal pooled plasma or FXI deficient plasma were stimulated with Alexin (1/80) in the presence of 10 μg/ml antibody 5061 or mouse IgG. Each sample was tested in triplicates.