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Interfering with miR-122 inhibits HCV replication. (A) Alignment of miR-122-binding sites in HCV 5′ NTR of genotype 1b Con1 and genotype 2a JFH-1. (B and C) 2′-O-methylated RNAs targeting a random sequence (Rand) or miR-122 (miR-122) were introduced into Huh7.5 cells, infected with HCV, and harvested at the indicated time points, and HCV RNA (B) and infectious virus (C) was quantified. Values are averages of triplicates ± SEM. P value < 0.001.
