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Presence of KIR2DS3 in the donor protects against chronic GHVD. Kaplan-Meier analysis and Cox proportional hazard modeling of chronic GVHD in all patients (n=143) transplanted from (i) donors with KIR2DS3 absent (n=63/106) compared to (ii) donors with KIR2DS3 present (n=15/37, p=0.03; hazard ratio=0.5, 95% CI=0.3-0.9).
