Table 1.

Summary of deletions/insertions in V_H gene rearrangements

Cell	VH gene*	Point mutations, n	Aberration	Length, bp	Location, region	Location, aa
Out-of-frame rearrangements
Ann 33	DP31	15	deletion	38	FRII-CDRII	42-54
Ann 38	DP4	9	deletion	21	FRIII	66-73
Ann 40	DP25	4	deletion	89	CDRI-CDRII	31-59
			deletion	59	FRIII	66-83
Ann 47	V3-35	2	deletion/insertion	195/35	CDRI-FRIII	31-91
G1-8	DP10	9	duplication	80	CDRIII-FRIV	96-8 bp
						JH-intron
G2-29	DP7	20	duplication	131	CDRII-CDRIII	61-100d
G2-55†	V3-43	19	deletion	17	CDRII	52-57
			deletion	16	FRIII	73-78
			duplication	28	FRIII	81-87
			duplication	52	CDRIII	99-100q
G2-67	DP49	16	deletion	20	FRIII	83-89
G2-74†	V3-11	7	insertion	1	FRIII	93
			deletion	206	JH4-JH4/5	109-194 bp
					Intron	JH-intron
G2-80	V3-30	13	deletion	7	FRIII	75-77
			deletion	20	FRIII	84-90
G2-95†	DP75	10	deletion	>268	FRIII-JH4/5	82a-216 bp
					Intron	JH-intron
G2-112†	DP31	15	deletion	26	FRIII	76-82b
			duplication	111	CDRII-FRIII	53-86
			duplication	70	FRIII-CDRIII	80-100
In-frame rearrangements
Ann 36	DP42	9	insertion	9	CDRII	56
G1-8	V4-4b	7	deletion	1	FRIII	77
			deletion	4	FRIII	80/81
G2-56	DP79	6	deletion	3	FRIII	72/73

FR, framework region; CDR, complementarity-determining region. 

^*References for germ-line genes: DP4, DP7, DP10, DP25, DP31, DP 42, DP49, DP75, DP79 (19); V3-11, V3-30, V3-35, V3-43, V4-4b (20). 

^†Replicated V_H region genes were amplified in two separate reactions.