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. 1998 Mar 3;95(5):2469–2474. doi: 10.1073/pnas.95.5.2469

Figure 2.

Figure 2

CVB3 RNA is present in hearts of infected mice. Wild-type mice (MF1, 129, and MF1/129 hybrid F2) and NOS2 null mice (MF1/129 KO) were infected with 105 or 107 pfu of CVB3. Hearts were harvested from noninfected animals (lane 1) or from infected mice at times 1, 3, 5, 7, 10, and 15 days after infection (lanes 2–7 and lanes 8–13). The CVB3 genome was analyzed by Southern analysis of RT-PCR from total RNA (A). The Southern blot was quantitated by densitometry for mice infected with (B) 105 pfu CVB3 or (C) 107 pfu CVB3. For B and C the differences between the NOS2 null mice and the MF1/129 wild-type mice at each time point have a P < 0.001 (n = 3 mice per RT-PCR ± SD although the error bars are not visible).