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. 1998 Mar 3;95(5):2469–2474. doi: 10.1073/pnas.95.5.2469

Figure 3.

Figure 3

CVB3 infectious particles are present in hearts of infected mice. Wild-type mice (MF1, 129, and MF1/129 hybrid F2) and NOS2 null mice (MF1/129 KO) were infected with (A) 105 or (B) 107 pfu CVB3. Hearts were harvested from noninfected animals or from infected mice at times 1, 3, 5, 7, 10, and 15 days after infection. The amount of CVB3 pfu/mg of tissue was determined by the plaque assay. For A the differences between the NOS2 null mice and the MF1/129 wild-type mice at days 7, 10, and 15 have a P < 0.01. For B the differences between the NOS2 null mice and all other mice at all time points have a P < 0.001 (n = triplicate measurements from each of 3 mice ± SD).