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Lesions in hearts of infected mice. Wild-type mice (MF1, 129, and MF1/129 hybrid F2) and NOS2 null mice (MF1/129 KO) were infected with (A) 105 or (B) 107 pfu of CVB3. Hearts were harvested from noninfected animals or from infected mice. Tissue sections were stained with hematoxylin and eosin, and the number of lesions was counted. The difference between the NOS2 null mice and all controls is P < 0.001 (n = 3 sections from each of 3 mice ± SD).
