TABLE 1.
Molecular analysis of the 113 B. cepacia complex isolates examined in this worka
Patient | Gender | Age | Isolate | Isolation date (day/mo/yr) | Ribotype | Genomovar or species | recA | cblA | BCESM | Clinical outcome |
---|---|---|---|---|---|---|---|---|---|---|
A | F | 4 mo | IST401 | 28/8/95 | 2 | Genomovar I | K | − | − | |
5 mo | IST404 | 5/9/95 | 3 | Genomovar III-B | H | − | − | Era | ||
B | M | 19 yr | IST402 | 13/4/95 | 1 | B. stabilis | J | − | − | |
IST409 | 24/4/95 | 1 | B. stabilis | J | − | − | ||||
IST421 | 3/4/98 | 1 | B. stabilis | J | − | − | ||||
IST428 | 28/9/98 | 1 | B. stabilis | J | − | − | ||||
IST437 | 25/1/99 | 1 | B. stabilis | J | − | − | Det | |||
C | F | 12 yr | IST403 | 14/2/95 | 7 | Genomovar III-A | G | − | + | Unk |
D | F | 4 mo | IST407 | 6/12/95 | 3 | Genomovar III-B | H | − | + | Era |
E | M | 3 mo | IST406 | 15/12/95 | 2 | Genomovar I | K | − | − | D/unr |
F | F | 2 yr | IST408 | 31/1/95 | 2 | Genomovar I | K | − | − | D/unr |
G | F | 10 yr | IST405 | 7/4/95 | 4 | Genomovar III-B | I | − | + | |
IST410 | 1/6/95 | 5 | Genomovar I | K | − | − | ||||
IST411 | 9/12/95 | 6 | Genomovar III-B | I | − | + | D/cs | |||
H | F | 19 yr | IST412 | 21/1/97 | 1 | B. stabilis | J | − | − | |
IST413 | 18/3/97 | 1 | B. stabilis | J | − | − | ||||
IST414 | 13/5/97 | 1 | B. stabilis | J | − | − | ||||
IST415 | 8/7/97 | 1 | B. stabilis | J | − | − | ||||
IST420 | 11/3/98 | 1 | B. stabilis | J | − | − | ||||
IST423 | 6/5/98 | 1 | B. stabilis | J | − | − | ||||
IST425 | 7/7/98 | 1 | B. stabilis | J | − | − | ||||
IST427 | 13/8/98 | 1 | B. stabilis | J | − | − | ||||
IST446 | 13/3/99 | 1 | B. stabilis | J | − | − | ||||
IST448 | 4/6/99 | 1 | B. stabilis | J | − | − | ||||
IST451 | 7/1/99 | 1 | B. stabilis | J | − | − | D/cs | |||
I | F | 4 yr | IST416 | 30/9/97 | 8 | Genomovar III-A | G | − | + | Era |
J | F | 17 yr | IST418 | 30/1/98 | 1 | B. stabilis | J | − | − | |
IST419 | 1/2/98 | 9 | B. multivorans | F | − | − | ||||
IST424 | 4/6/98 | 9 | B. multivorans | F | − | − | ||||
IST439 | 30/1/99 | 11 | Genomovar III-A | G | − | + | ||||
IST453 | 19/7/99 | 9 | B. multivorans | F | − | − | ||||
IST455 | 7/2/00 | 9 | B. multivorans | F | − | − | ||||
IST461 | 4/4/00 | 9 | B. multivorans | F | − | − | ||||
IST483 | 29/3/01 | 11 | Genomovar III-A | G | − | + | ||||
IST495 | 29/5/01 | 9 | B. multivorans | F | − | − | ||||
IST4103 | 28/7/01 | 11 | Genomovar III-A | G | − | + | ||||
IST4110 | 1/10/01 | 11 | Genomovar III-A | G | − | + | ||||
IST4112 | 11/10/01 | 11 | Genomovar III-A | G | − | + | ||||
IST4113 | 6/11/01 | 11 | Genomovar III-A | G | − | + | ||||
IST4119 | 22/1/02 | 9 | B. multivorans | F | − | − | ||||
IST4116 | 11/2/02 | 11 | Genomovar III-A | G | − | − | ||||
IST4129 | 26/3/02 | 11 | Genomovar III-A | G | − | + | ||||
IST4130 | 14/5/02 | 11 | Genomovar III-A | G | − | + | ||||
IST4131 | 26/2/02 | 11 | Genomovar III-A | G | − | + | D/cs | |||
L | F | 2 mo | IST426 | 22/7/98 | 10 | NT | NT | + | − | Era |
N | F | 12 yr | IST431 | 30/8/98 | 12 | Genomovar I | AG | − | − | |
IST443 | 3/3/99 | 12 | Genomovar I | AG | + | − | ||||
IST444 | 3/3/99 | 12 | Genomovar I | AG | + | − | ||||
IST449 | 9/6/99 | 12 | Genomovar I | AG | + | − | ||||
IST457 | 15/3/00 | 12 | Genomovar I | AG | + | − | ||||
IST463 | 23/5/00 | 12 | Genomovar I | AG | + | − | ||||
IST472 | 18/10/00 | 12 | Genomovar I | AG | + | − | ||||
IST485 | 1/4/01 | 12 | Genomovar I | AG | + | − | ||||
IST491 | 26/4/01 | 12 | Genomovar I | AG | + | − | ||||
IST4104 | 16/8/01 | 12 | Genomovar I | AG | + | − | ||||
IST4105 | 31/8/01 | 12 | Genomovar I | AG | + | − | ||||
IST4106 | 24/9/01 | 12 | Genomovar I | AG | + | − | ||||
IST4115 | 8/11/01 | 12 | Genomovar I | AG | + | − | ||||
IST4117 | 3/1/02 | 12 | Genomovar I | AG | + | − | D/r | |||
O | F | 9 yr | IST430 | 30/9/98 | 11 | Genomovar III-A | G | − | + | |
IST435 | 1/11/98 | 14 | Genomovar III-B | H | − | − | ||||
IST440 | 8/2/99 | 14 | Genomovar III-B | H | − | − | ||||
IST450 | 9/6/99 | 14 | Genomovar III-B | H | − | − | ||||
IST458 | 17/3/00 | 14 | Genomovar III-B | H | − | − | ||||
IST462 | 23/5/00 | 11 | Genomovar III-A | G | − | − | ||||
IST467 | 19/7/00 | 11 | Genomovar III-A | G | − | + | ||||
IST470 | 18/10/00 | 11 | Genomovar III-A | G | − | + | ||||
IST471 | 18/10/00 | 14 | Genomovar III-B | H | − | − | ||||
IST478 | 15/02/01 | 11 | Genomovar III-A | G | − | + | ||||
IST486 | 3/4/01 | 11 | Genomovar III-A | G | − | + | ||||
IST490 | 26/4/01 | 11 | Genomovar III-A | G | − | + | ||||
IST497 | 31/5/01 | 11 | Genomovar III-A | G | − | + | ||||
IST4107 | 17/9/01 | 11 | Genomovar III-A | G | − | + | ||||
IST4114 | 8/11/01 | 14 | Genomovar III-B | H | − | − | /PICK> | |||
IST4118 | 3/1/02 | 14 | Genomovar III-B | H | − | − | ||||
IST4123 | 28/2/02 | 14 | Genomovar III-B | H | − | − | ||||
IST4128 | 2/5/02 | 12 | Genomovar I | AG | + | − | Det | |||
P | F | 6 yr | IST432 | 14/9/98 | 13 | Genomovar III-A | G | − | − | |
IST468 | 17/10/00 | 13 | Genomovar III-A | G | − | − | ||||
IST489 | 19/4/01 | 13 | Genomovar III-A | G | − | − | Sta | |||
Q | F | 11 yr | IST433 | 5/11/98 | 14 | Genomovar III-B | H | − | − | D/unr |
R | F | 1 yr | IST438 | 25/1/99 | 15 | Genomovar III-B | AN | − | − | |
IST445 | 8/3/99 | 15 | Genomovar III-B | AN | − | − | ||||
IST452 | 12/7/99 | 15 | Genomovar III-B | AN | − | − | ||||
IST454 | 30/12/99 | 15 | Genomovar III-B | AN | − | − | ||||
IST456 | 15/3/00 | 15 | Genomovar III-B | AN | − | − | ||||
IST465 | 31/5/00 | 15 | Genomovar III-B | AN | − | − | ||||
IST474 | 15/1/01 | 15 | Genomovar III-B | AN | − | − | ||||
IST475 | 20/1/01 | 15 | Genomovar III-B | AN | − | − | ||||
IST476 | 19/1/01 | 15 | Genomovar III-B | AN | − | − | ||||
IST484 | 29/3/01 | 15 | Genomovar III-B | AN | − | − | Sta | |||
T | M | 15 yr | IST466 | 12/6/00 | 16 | Genomovar III-B | H | − | + | |
IST469 | 18/10/00 | 16 | Genomovar III-B | H | − | + | ||||
IST473 | 27/12/00 | 16 | Genomovar III-B | H | − | + | ||||
IST479 | 19/2/01 | 16 | Genomovar III-B | H | − | + | ||||
IST4102 | 12/7/01 | 16 | Genomovar III-B | H | − | + | ||||
IST4109 | 4/10/01 | 16 | Genomovar III-B | H | − | + | D/r | |||
U | F | 6 yr | IST494 | 10/5/01 | 1 | B. stabilis | J | − | − | |
IST4124 | 28/2/02 | 1 | B. stabilis | J | − | − | Sta | |||
W | M | <1 yr | IST480 | 21/2/01 | 2 | Genomovar I | K | − | − | |
IST487 | 6/4/01 | 2 | Genomovar I | K | − | − | ||||
IST488 | 21/4/01 | 2 | Genomovar I | K | − | − | ||||
IST492 | 7/5/01 | 2 | Genomovar I | K | − | − | ||||
IST493 | 10/5/01 | 2 | Genomovar I | K | − | − | ||||
IST4101 | 4/7/01 | 2 | Genomovar I | K | − | − | Sta | |||
V | F | 3 yr | IST481 | 28/2/01 | 3 | B. cepacia complex | H2 | − | − | Sta |
Y | M | 10 yr | IST4108 | 21/9/01 | 9 | B. multivorans | F | − | − | |
IST4111 | 12/10/01 | 9 | B. multivorans | F | − | − | ||||
IST4122 | 31/1/02 | 9 | B. multivorans | F | − | − | ||||
IST4125 | 11/4/02 | 9 | B. multivorans | F | − | − | Sta | |||
X | M | 5 yr | IST4120 | 24/1/02 | 2 | Genomovar I | K | − | − | |
IST4126 | 18/4/02 | 2 | Genomovar I | K | − | − | Sta | |||
AB | M | 14 yr | IST4121 | 31/1/02 | 7 | Genomovar III-A | G | + | − | Det |
All the serial isolates obtained from the same patient (male [M] or female [F]) during the 7-year surveillance period, the date of isolation, the age of the patient at the time of first isolation, and the clinical outcome (at the time of last isolation), are indicated. Abbreviations: NT, not tested; Era, eradicated B. cepacia infection; Det, deteriorated; Unk, unknown; D/unr, deceased, death unrelated to B. cepacia infection; D/cs, Deceased with the cepacia syndrome; Sta, stable; D/r, deceased, death related to B. cepacia infection.