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Zinc-binding alters the CD spectrum of HIV-1 integrase in the near UV region. (A) Near UV CD spectra of integrase (IN1–288/F185K/C280S) in the absence (solid line) and presence (dotted line) of bound zinc. (B) Near UV CD spectra of IN1–288/H12N/H16N/F185K/C280S) in the absence (solid line) and presence (dotted line) of bound zinc. The substitution of Asn for His in the HHCC motif abolishes the effect of zinc on the near UV CD spectrum.
