TABLE 3.
Tissue biopsy specimens from patients at risk of aspergillosis
| No. | Age/sex | Underlying diseasea | Tissue | Culture | PCR | S-agc | Diagnosis |
|---|---|---|---|---|---|---|---|
| 1 | 25/M | ALL | Lung | A. flavus | Negative | Positive (×3) | IPA (proven) |
| 2 | 27/M | ALL | Brain | Negative (hyphae seen) | Positive | Positive (×3) | IA (proven) |
| Kidney | A. fumigatus | Positive | |||||
| Brain | Not done | Negative | |||||
| Liver biopsy | Not done | Positive | |||||
| Spleen | No fungal growth | Positive | |||||
| 3 | 53/M | Collagenosis, DM | Brain | A. fumigatus | Positive | Positive | Rhinocerebral aspergillosis |
| 4 | 31/M | MDS, MUD transplantation | Lung | No fungal growth | Negative | Positive (X2) | IA (CNS, post mortem) |
| 5 | 66/M | Aplastic anemia/BMT | Liver | No fungal growth | Negative | Positive | IA (probable)b |
| 6 | 57/M | CLL | Lung | A. fumigatus | Positive | Positive (×4) | IPA (proven) |
| Liver | Not done | Negative | |||||
| 7 | 54/M | AML | Lung | C. tropicalis | Negative | Negative | Sepsis (C. tropicalis) |
| Liver | C. albidus, Acremonium sp. | Negative | |||||
| 8 | 29/F | ALL | Lung | No fungal growth | Negative | Negative | Mucormycosis (histology) |
| 9 | 49/M | NHL | Lung | C. albicans | Negative | Negative | Pneumonia |
| 10 | 70/F | MDS-AML | Lung | C. albicans | Negative | Negative | Pneumonia |
a
ALL, acute lymphoblastic leukemia; DM, diabetes mellitus; MDS, myelodysplastic syndrome; MUD, matched unrelated donor; BMT, bone marrow transplantation; CLL, chronic lymphocytic leukemia; AML, acute myelogenous leukemia; NHL, non-Hodgkin's lymphoma.
b
RCT of liver was consistent with invasive fungal infection.
c
S-ag, galactomannan antigen in serum. Values in parentheses are the numbers of separate serum samples in which galactomannan antigen was detected.