Figure 1.

Distribution of c-Kit⁺ or IL-7Rα⁺ cells in either MHC-DKO, MHC-IKO, MHC-IIKO, or MHC^+/+ thymus. (A) The CD4/CD8 profiles of total thymocytes (Top), those of c-Kit⁺ cells (Middle), and those of IL-7Rα⁺ cells (Bottom). Squares indicate the definition of DN, DP^lo, DP^int, DP^hi, and TI (CD4⁺CD8^med or CD4^medCD8⁺) stages in this study. (B) The TCRβ/c-Kit (Upper) and the TCRβ/IL-7R (Lower) profiles of total thymocytes. Note that MHC-DKO mice lack the TCR^med-hi c-Kit⁺ and TCR^med-hi IL-7R⁺ populations.