TABLE 6.
Comparison of HC2 and HC3 HPV type specificity with MY09 L1 consensus primer PCR results available for 1,247 specimensa
| HPV group (PCR) | No. (%) of cases
|
||||
|---|---|---|---|---|---|
| HC2−/HC3− | HC2−/HC3+ | HC2+/HC3− | HC2+/HC3+ | Total | |
| Negative | 139 (53.6) | 8 (3.1) | 68 (26.1) | 46 (18.5) | 261 (100.0) |
| Untargeted types | 132 (51.6) | 5 (2.1) | 62 (25.4) | 45 (18.4) | 244 (100.0) |
| Targeted types | 118 (15.9) | 17 (2.3) | 29 (3.9) | 578 (77.9) | 742 (100.0) |
| Total | 389 | 30 | 159 | 669 | 1,247 |
a
PCR data were classified hierchically: targeted types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68), if not target then untargeted types, else negative. HC2 (1.0-pg/ml cut point) and HC3 (0.6-pg/ml cut point) data were categorized by whether both tests were negative (HC2−/HC3−), HC2 was negative but HC3 was positive (HC2−/HC3+), HC2 was positive but HC3 was negative (HC2+/HC3−), or both tests were positive (HC2+/HC3+). Raw percentages are shown in italics. P < 0.001, Pearson χ2, overall; P < 0.001, Pearson χ2; HC2−/HC3+ versus HC2+/HC3−.