TABLE 1.

S. cerevisae longevity genes

Longevity gene	Relevant function of gene product	Overexpression or mutation increases life spana	Increases rDNA silencing/stability?	Reference
Replicative life span
CDC25	Glucose response signaling pathway	M	Yes	114
CYR1	Glucose response signaling pathway	M	?	114
FOB1	Replication fork block; contributes to rDNA instability	M	Yes	37
GPR1	Glucose response signaling pathway	M	?	114
GPA2	Glucose response signaling pathway	M	?	114
HAP4	Heme-activated transcription factor; induces respiration	O	Yes	115
LAG1	Synthesis of ceramides and inositol phosphorylceramide	M	?	35
LAG2	Transmembrane domain containing protein	O	?	29
NPT1	NAD biosynthesis	O	Yes	2
NMA1/2	NAD biosynthesis	O	Yes	2
PNC1	NAD biosynthesis	O	Yes	3
RAS1	Glucose response signaling pathway	M	?	194
RAS2	Glucose response signaling pathway	O	?	194
RPD3	Histone deacetylase, affects rDNA silencing	M	Yes	79
RTG3	Transcription factor that transduces mitochondrial signals	M	?	78
SIP2	Repressor of the Snf1 serine/threonine kinase	O	Yes	117
SNF4	Activator of Snf1	M	Yes	117
SIR2	NAD+-dependent HDAC; stabilizes rDNA	O	Yes	88
SIR4	Associates with Sir2; Sir4-42 extends life span	M	?	92
TPK1	Glucose response pathway	M	?	114
UTH1	Unknown function; responds to oxidative stress	M	Yes	92
UTH4	Localization of Sir complex	M	Yes	54
ZDS1	Deletion increases silencing at rDNA locus	M	Yes	163
Chronological life span
CYR1	Glucose response signaling pathway	M	?	45
RAS2	Glucose response signaling pathway	M	?	44
SCH9	Protein kinase Akt/PKB homolog	M	?	45
SOD1/SOD2	Cytosolic/mitochondrial superoxide dismutases	O	?	125

^aO, overexpression; M, mutation.